Spyre Therapeutics, Inc. - Common Stock (SYRE)
Healthcare › Pharmaceutical Preparations
Price History
Feb 9, 2026 — Aug 4, 2026Investment Snapshot
- P/B of 12.29 — trading above book value
- Piotroski F-Score 1/9 — signs of financial weakness
- Loss-making — negative ROE of -24.1%
- Revenue declining 100% annually
Spyre Therapeutics, Inc. - Common Stock (SYRE) is a Healthcare company operating in Pharmaceutical Preparations, listed on the NASDAQ , with a market capitalisation of $8.2 billion . Key value metrics: P/B ratio 12.29, Piotroski F-Score 1 out of 9 .
Value Score
Key Metrics
Current vs 5-Year Average
Based on 5 years of SEC filingsRevenue & Net Income
Financial Statements
| Metric | FY22 | FY23 | FY24 |
|---|---|---|---|
| Revenue | $X.XB | $X.XB | $X.XB |
| Gross Profit | $X.XB | $X.XB | $X.XB |
| Operating Income | $X.XB | $X.XB | $X.XB |
| Net Income | $X.XB | $X.XB | $X.XB |
| EBITDA | $X.XB | $X.XB | $X.XB |
| Total Assets | $X.XB | $X.XB | $X.XB |
| Total Liabilities | $X.XB | $X.XB | $X.XB |
Spyre Therapeutics, Inc. - Common Stock — Fundamental Analysis Summary
On financial health, SYRE shows a weak Piotroski F-Score of 1/9, a signal of deteriorating financial health, and negative return on equity of -24.1% (sector average: -20.1%), and minimal leverage with a debt-to-equity ratio of 0.09.
StockPik's composite Value Score for SYRE is 25/100 — reflecting current market or financial concerns. The score is built from ten fundamental signals: P/E, P/B, PEG ratio, P/S ratio, return on equity, gross margin, debt-to-equity, current ratio, dividend yield, and Piotroski F-Score.
SYRE shows revenue declining at 100% year-over-year, with earnings growing at 25%.