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Denali Therapeutics Inc. - Common Stock (DNLI)

NASDAQ Mid Cap

Healthcare › Biological Products, (No Diagnostic Substances)

$18.92
Market Cap: $3.0B
Data as of Sep 30, 2025 (TTM)

Price History

Feb 9, 2026 — May 6, 2026

Investment Snapshot

  • P/B of 2.96 — trading above book value
  • Piotroski F-Score 2/9 — signs of financial weakness
  • Loss-making — negative ROE of -48.5%
  • Revenue declining 100% annually

Denali Therapeutics Inc. - Common Stock (DNLI) is a Healthcare company operating in Biological Products, (No Diagnostic Substances), listed on the NASDAQ , with a market capitalisation of $3.0 billion . Key value metrics: P/B ratio 2.96, Piotroski F-Score 2 out of 9 .

Value Score

Key Metrics

P/E Ratio
2.96
EPS
$-3.10
Div. Yield
PEG Ratio
P/S Ratio
EV/EBITDA
ROE
ROA
Gross Margin
Op. Margin
Net Margin
Debt/Equity
Current Ratio

Current vs 5-Year Average

Based on 5 years of SEC filings
Net Margin
↑ +2.1pp avg —
Gross Margin
↑ +2.1pp avg —
Operating Margin
↑ +2.1pp avg —
Return on Equity
↑ +2.1pp avg —
Debt / Equity
↑ +2.1pp avg —

Revenue & Net Income

EPS & Free Cash Flow Per Share

Financial Statements

Metric FY22 FY23 FY24
Revenue $X.XB $X.XB $X.XB
Gross Profit $X.XB $X.XB $X.XB
Operating Income $X.XB $X.XB $X.XB
Net Income $X.XB $X.XB $X.XB
EBITDA $X.XB $X.XB $X.XB
Total Assets $X.XB $X.XB $X.XB
Total Liabilities $X.XB $X.XB $X.XB
Data sourced from SEC EDGAR and Polygon.io. Methodology. View more Healthcare stocks →

Denali Therapeutics Inc. - Common Stock — Fundamental Analysis Summary

On financial health, DNLI shows a weak Piotroski F-Score of 2/9, a signal of deteriorating financial health, and negative return on equity of -48.5% (sector average: -20.6%), and minimal leverage with a debt-to-equity ratio of 0.13.

StockPik's composite Value Score for DNLI is 40/100 — reflecting current market or financial concerns. The score is built from ten fundamental signals: P/E, P/B, PEG ratio, P/S ratio, return on equity, gross margin, debt-to-equity, current ratio, dividend yield, and Piotroski F-Score.

DNLI shows revenue declining at 100% year-over-year, with earnings declining at 21%.

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How is the Value Score calculated?
Read our full methodology →
What is the Piotroski F-Score?
The 9-point financial health score explained, with worked examples →
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