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Castle Biosciences, Inc. - Common stock (CSTL)

NASDAQ Small Cap

Healthcare › Services-Medical Laboratories

$25.52
Market Cap: $759M
Data as of Sep 30, 2025 (TTM)

Price History

Feb 9, 2026 — May 5, 2026

Investment Snapshot

  • Trading 66% above Graham Number — above intrinsic value estimate
  • Piotroski F-Score 3/9 — signs of financial weakness
  • Loss-making — negative ROE of -4.2%

Castle Biosciences, Inc. - Common stock (CSTL) is a Healthcare company operating in Services-Medical Laboratories, listed on the NASDAQ , with a market capitalisation of $759 million . Key value metrics: P/E ratio 38.7, P/B ratio 1.61, Piotroski F-Score 3 out of 9 .

Value Score

Key Metrics

P/E Ratio
38.67
1.61
EPS
$-0.66
Div. Yield
PEG Ratio
P/S Ratio
EV/EBITDA
ROE
ROA
Gross Margin
Op. Margin
Net Margin
Debt/Equity
Current Ratio

Current vs 5-Year Average

Based on 5 years of SEC filings
Net Margin
↑ +2.1pp avg —
Gross Margin
↑ +2.1pp avg —
Operating Margin
↑ +2.1pp avg —
Return on Equity
↑ +2.1pp avg —
Debt / Equity
↑ +2.1pp avg —

Revenue & Net Income

EPS & Free Cash Flow Per Share

Financial Statements

Metric FY22 FY23 FY24
Revenue $X.XB $X.XB $X.XB
Gross Profit $X.XB $X.XB $X.XB
Operating Income $X.XB $X.XB $X.XB
Net Income $X.XB $X.XB $X.XB
EBITDA $X.XB $X.XB $X.XB
Total Assets $X.XB $X.XB $X.XB
Total Liabilities $X.XB $X.XB $X.XB
Data sourced from SEC EDGAR and Polygon.io. Methodology. View more Healthcare stocks →

Castle Biosciences, Inc. - Common stock — Fundamental Analysis Summary

Castle Biosciences, Inc. - Common stock (CSTL) is currently trading 66% above its Graham Number of $15.42, suggesting the market price exceeds Benjamin Graham's intrinsic value estimate. The stock carries an elevated trailing P/E ratio of 38.7x.

On financial health, CSTL shows a weak Piotroski F-Score of 3/9, a signal of deteriorating financial health, and negative return on equity of -4.2% (sector average: -20.6%), and minimal leverage with a debt-to-equity ratio of 0.02.

StockPik's composite Value Score for CSTL is 59/100 — an above-average value rating. The score is built from ten fundamental signals: P/E, P/B, PEG ratio, P/S ratio, return on equity, gross margin, debt-to-equity, current ratio, dividend yield, and Piotroski F-Score.

CSTL reports a high gross margin of 80.1% (sector average: 40.1%) and a negative operating margin of -9.9%.

CSTL shows revenue growing at 4% year-over-year, with earnings declining at 232%.

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How is the Value Score calculated?
Read our full methodology →
How is the Graham Number calculated?
Benjamin Graham's intrinsic value formula, worked examples, and how to use it →
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